The Center for Systems Biology, University of Iceland is looking to recruit a highly motivated postdoctoral fellow to join a collaborative effort funded by the Swiss Initiative in Systems Biology. The project, BattleX, focuses on manipulating the fight between human host cells and intracellular pathogens.
The research at the CSB UoI focuses on 1> human metabolism and 2> industrial biotechnology. In particular, the CSB UoI aims to characterize human disease using a systems biology approach. This research effort includes on 1> expanding the currently available human metabolic reconstruction, 2> discovery of new functions and pathways in human metabolism using computational and experimental techniques, 3> phenotyping of human cell lines using metabolomic techniques, 4> computational and experimental analysis of metabolic changes associated with disease, and 5> high-throughput drug screening. We use the state-of-the-art computational methods to guide and design human cell culturing experiments as well as metabolomic measurements. These technologies are embedded in a biologically driven research program that aims at systematic understanding of human metabolism, disease manifestation and drug target identification. The Center is an interdisciplinary center with the Schools of Medic!
ine, Engineering and Natural Sciences participating. The CSB UoI provides a scientifically stimulating, innovative, dynamic, well- equipped, and international surrounding.
The successful candidate will be employed by University of Basel. The successful candidate will be working in close collaboration with the Swiss groups involved in the BattleX project. The main research work of the successful candidate will take place at the CSB UoI in Reykjavik. The successful candidate should be prepared to travel 1 -2 times per year between the CSB UoI and the Bumann Group at the University of Basel.
Job description:
• Expansion and refinement of the human metabolic reconstruction.
• Identification of missing metabolic genes using bioinformatics and modeling tools .
• Annotation of human metabolic gene functions.
• Development of cell type specific metabolic models from experimental data and the human metabolic reconstruction.
• The project will thus include key technologies used in computational systems biology and bioinformatics.
Your qualifications:
• Doctoral degree in Bioinformatics, Systems Biology, Biochemistry, Biotechnology or Medicine.
• Strong background in gene function annotation in mammalian genomes.
• Strong programming skills and experience in statistical data analysis.
• Excellent communication skills and team orientated work.
• Excellent knowledge of written and spoken English.
• An international research experience is advantageous.
The position is available immediately. Please send a cover letter, a brief description of research experience and interests, a curriculum vitae and contact information for three references in pdf file form to Ines Thiele, Ph.D., . All applications will be answered and applicants will be informed about the appointment when a decision has been made.
Further information:
Thiele Lab: http://www.hi.is/~ithiele/
Bumann Lab: http://www.biozentrum.unibas.
BattleX: http://www.systemsx.ch/
CSB UoI: http://systemsbiology.is/
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