Based on a grant by the German National Research Foundation (DFG) this project aims at understanding the biological roles of protein arginylation in the moss Physcomitrella patens.
Until recently, the incorporation of arginine into proteins has been associated almost exclusively with ribosomal protein synthesis. However, it is becoming increasingly clear, that post-translational arginylation of some proteins is linked to N-terminal modification during the ubiquitin proteasome pathway. For other classes of proteins, it leads to changes in protein functionality. The enzyme responsible for arginylation is the arginyl-tRNA protein transferase (Ate) that transfers the activated form of arginine from arginyl-tRNA to specific a-amino groups of proteins. Within the project the role of Ate and its implications for the protein arginylation of identified targets will be investigated utilizing a large spectrum of molecular biology techniques, including the generation of knockout mosses.
We offer a stimulating international working environment in one of the nicest German cities. The successful candidate will work under supervision of Dr. Gabor Igloi (Genetics), Dr. Andreas Schlosser (Proteomics) and Prof. Dr. Ralf Reski (Plant Biotechnology).
The successful candidate has a Masters or a Diploma in Biology, or equivalent, and is experienced in molecular biology techniques. Experience with plant biology is advantageous.
The application process is open until May 1st, 2010. According to our structured PhD studies program, initial payment is guaranteed for the first year and will be prolonged for the second and third year after positive evaluation of the PhD student's progress. The University of Freiburg is committed to increase the quota of women and we encourage women to submit their applications. The physically disabled will be preferred if equally qualified.
Please send your application as a single pdf-file by email to:pbt@biologie.uni-freiburg.de
Until recently, the incorporation of arginine into proteins has been associated almost exclusively with ribosomal protein synthesis. However, it is becoming increasingly clear, that post-translational arginylation of some proteins is linked to N-terminal modification during the ubiquitin proteasome pathway. For other classes of proteins, it leads to changes in protein functionality. The enzyme responsible for arginylation is the arginyl-tRNA protein transferase (Ate) that transfers the activated form of arginine from arginyl-tRNA to specific a-amino groups of proteins. Within the project the role of Ate and its implications for the protein arginylation of identified targets will be investigated utilizing a large spectrum of molecular biology techniques, including the generation of knockout mosses.
We offer a stimulating international working environment in one of the nicest German cities. The successful candidate will work under supervision of Dr. Gabor Igloi (Genetics), Dr. Andreas Schlosser (Proteomics) and Prof. Dr. Ralf Reski (Plant Biotechnology).
The successful candidate has a Masters or a Diploma in Biology, or equivalent, and is experienced in molecular biology techniques. Experience with plant biology is advantageous.
The application process is open until May 1st, 2010. According to our structured PhD studies program, initial payment is guaranteed for the first year and will be prolonged for the second and third year after positive evaluation of the PhD student's progress. The University of Freiburg is committed to increase the quota of women and we encourage women to submit their applications. The physically disabled will be preferred if equally qualified.
Please send your application as a single pdf-file by email to:pbt@biologie.uni-freiburg.de
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