A PhD student fellowship is available by the DFG-funded International Research Training Group (Internationales Graduiertenkolleg GRK 1384 of the DFG) "Enzymes and multienzyme complexes acting on nucleic acids" in the group "Molecular Microbiology" of Prof. Dr. Gabriele Klug at the Institute of Microbiology and Molecular Biology (Faculty of Biology) of the Justus-Liebig-University in Giessen (Germany) from 1st of June 2010.
The Training Group provides an intriguing research environment including seminars, workshops, training courses, assessment of progress and success and collaborations. The Training Group collaborates with the respective training group at the M.V. Lomonosov-University, Moscow, Russian Federation.
The fellowship (1200 Euro per month) is currently limited to the end of March 2011, but prolongation shall be made possible. Graduation will proceed in the Faculty of Biology and Chemistry of the University of Giessen to achieve a Dr. rer. nat. (PhD equivalent).
Project description:
We have described the existence of the RNA degrading and RNA tailing exosome in the hyperthermophilic archaeon Sulfolobus solfataricus (Evguenieva-Hackenberg et al. 2003, EMBO reports 4: 889-893) and have further analyzed its biochemical properties and substrate selectivity (Evguenieva-Hackenberg et al., Biochemistry 2008, Roppelt et al., submitted). The research will focus on the role of the individual domains of the subunits Rrp4 (N-terminal, S1 and KH domains) and Csl4 (N-terminal, S1 and Zn-ribbon domain) in selection and/or unwinding of RNA substrates. The work will include handling of radioactively labeled transcripts.
Prerequisites:
Applicants should hold a M.Sc. or Diploma degree in biology or a related life science discipline. Candidates should be highly motivated and should have a strong background in molecular biology and biochemistry. Courses in the PhD program are taught in English. Therefore, a working knowledge of English is mandatory, whereas speaking German is useful, but not strictly required. Applications of candidates not speaking German are welcome.
The Justus-Liebig University Giessen is an equal opportunity employer. Applications of severely disabled with the same suitability are preferred.
In your application, please include the following documents as PDF files:
1. a brief letter of motivation (1/2 page)
2. a brief CV (maximum 2 pages) with a detailed personal data sheet (a complete list of education and employment times)
3. a photographic portrait image of the applicant
4. degree certificates
5. examination results (transcripts of B.Sc./Vordiplom and M.Sc./Diplom)
6. a summary of the M.Sc./Diploma thesis
7. a brief description of the main emphasis of studies and experimental work (if applicable, max. 1 page).
Applications should be handed in until April 30. Please send your application by Email with the subject line "Sulfolobus exosome-fellowship" to:
Gabriele.Klug@mikro.bio.uni-giessen.de
Please do not hand in your application by surface mail; the documents will not be sent back but will be destroyed after the application procedure.
Please do not hesitate to contact Gabriele Klug for further information.
Prof. Dr. Gabriele Klug
Institut für Mikrobiologie und Molekularbiologie, IFZ
Heinrich-Buff-Ring 26-32
35392 Giessen
Germany
Phone: +49-(0)641-99-35542
For more information and for publications, you may refer to:
http://www.uni-giessen.de/cms/fbz/fb08/biologie/mbio
Tentative Application Deadline : 30 April 2010
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